Oodles of Prague stuff here. Several of us have been--we go often.
You know there are NRT flights from MSP, DTW, ATL, JFK, SFO, PDX, SEA and LAX, don't you? Also one to Haneda airport (south of the city, I think) and one to Nagoya if you've never been there--also Fukuoka (yep--the airport code is first 3 letters...) but that connects NRT.
Check for Prague Music festival--it's May 12-June 3--hotels could be $ or scarce.
Prague Events
Whatever you decide, have fun! Ask away if you can get Prague.