If you're zedding IST-FRA, why not also have some LH tickets as back-up. I believe Lufthansa now has an e-zed agreement with Delta. There's an early morning LH flight from IST which would allow for a same day connection in FRA. Bear in mind that the taxes ex FRA to N. America are on the steep side (about 80 euro) and are also applied to transit passengers
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