When I was living in the states I put off going to STL as I was worried about safety. I eventually went and found it perfectly fine, the light rail takes you right downtown.
The arch is OK, get there early if you want to go inside and view as it sells out. Same with the Busch brewery... I've been to STL 4 times and still haven't been in the arch or the brewery as always sold out.
As for what else to do... there didn't seem to be much. Take a paddle boat along the Mississippi?
There is a great restaurant I went to with a friend in St Charles called Mother-In-Law Restaurant Greater St. Charles Convention & Visitors Bureau - a little pricey but quite good. The trailhead brewery is good too. I would have liked to have spent longer in historic St Charles, it's worth a visit (but think you'd need a car)
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