Thomas, first, I'm sorry to hear about your loss but it sounds so wonderful to have had that Alaska cruise with your wife. Memories of loved ones can be so cathartic.
If you all have zeds, you'd be able to go almost anywhere. What about Budapest? DL doesn't fly there anymore but it's almost as magical as Prague. You can get apts--look for JohnFarago (not FARGO, Mr. Lundegaard) in tripadvisor--he has at least one that would suit your needs. We stayed at a castle hotel on the Buda side: St. George Residence in Budapest, Hungary - Hotel Travel Deals
There is so much to do in Budapest--underground catacombs (spoooooky for the kids!) mineral baths and the Terror Museum. If they like history, it's a MUST. If they don't, make them go anyway--for the scary part. Central market is a blast for foods and they also have Christmas Markets (which are usually a huge ripoff but fun to walkabout) Paprika for gifts to take home--buy at major supermarkets or from farmer's markets. again, tripadvisor has one of the best forums for BUD. You can take a short side trip to Brno or small medieval towns for the day.
St. Stephen's cathedral would be a lovely place to light a candle for your wife.
You can also get apts in Prague--czech (haha) the posts here for more info from one of our members.
BTW--are the 6 others all "kids" or mix of adults and college ages?
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