Regarding the E2 bus...if money is no object, then a cab is fastest and only a few more dollars than the shuttle (when split between two people). But I'm a bit proponent of public transportation AND money IS an object, so I utilized the bus there recently. If you are traveling on a weekend day or holiday, I would advise against the bus, as it only goes to Poydras and Carrollton, which is not really near the french quarter, and, as we drove by, seemed moderately sketchy.
However, if you are traveling on weekdays during normal hours, the bus goes further down Poydras which is literally 3-4 blocks away from the French Quarter (about a 10-min walk to bourbon street), and a safe, populated area. (And it is only $1.60 each way) BUT, be sure to check the bus schedule first. There's a link to it from the MSY website. And I do think MSY is best and truly fully experienced overnight. I wouldn't even consider doing it as a day-trip.
But best of luck, and enjoy!!!
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