I've done trips like SAN-SFO-SYD-CNS/BNE and SAN-SFO-PVG/PEK and back in 3 days a bunch of times.

Craziest trips have been SAN-LAX-NRT-SIN-PEN or SAN-SFO-HKG-SGN. These would have been absolutely brutal if we weren't in first class.